Publications
2023
1. Anti-VEGF therapy selects for clones resistant to glucose starvation in ovarian cancer xenografts
Daniele Boso, Martina Tognon, Matteo Curtarello, Sonia Minuzzo, Ilaria Piga, Valentina Brillo, Elisabetta Lazzarini, Jessica Carlet, Ludovica Marra, Chiara Trento, Andrea Rasola, Ionica Masgras, Leonardo Caporali, Fabio Del Ben, Giulia Brisotto, Matteo Turetta, Roberta Pastorelli, Laura Brunelli, Filippo Navaglia, Giovanni Esposito, Angela Grassi, Stefano Indraccolo.
Journal of Experimental & Clinical Cancer Research
2. Plasma small-extracellular vesicles enriched in miR-122-5p promote disease aggressiveness in pediatric anaplastic large-cell lymphoma.
Carlotta Caterina Damanti, Lavinia Ferrone, Enrico Gaffo, Anna Garbin, Anna Tosato, Giorgia Contarini, Ilaria Gallingani, Roberta Angioni, Barbara Molon, Giulia Borile, Elisa Carraro, Marta Pillon, Federico Scarmozzino, Angelo Paolo Dei Tos, Marco Pizzi, Francesco Ciscato, Andrea Rasola, Alessandra Biffi, Stefania Bortoluzzi, Federica Lovisa, Lara Mussolin.
Cancer Communications
2022
1. The mitochondrial chaperone TRAP1 regulates F-ATP synthase channel formation.
Giuseppe Cannino, Andrea Urbani, Marco Gaspari, Mariaconcetta Varano, Alessandro Negro, Antonio Filippi, Francesco Ciscato, Ionica Masgras, Christoph Gerle, Elena Tibaldi, Anna Maria Brunati, Giorgio Colombo, Giovanna Lippe, Paolo Bernardi, Andrea Rasola.
Cell Death & Differentiation
2. Tumor growth of neurofibromin-deficient cells is driven by decreased respiration and hampered by NAD+ and SIRT3.
Ionica Masgras, Giuseppe Cannino, Francesco Ciscato, Carlos Sanchez-Martin, Fereshteh Babaei Darvishi, Francesca Scantamburlo, Marco Pizzi, Alessio Menga, Dolores Fregona , Alessandra Castegna, Andrea Rasola.
Cell Death & Differentiation
3. Protein Allostery and Ligand Design: Computational Design Meets Experiments to Discover Novel Chemical Probes.
Alice Triveri, Carlos Sanchez-Martin, Luca Torielli, Stefano A Serapian, Filippo Marchetti, Giovanni D'Acerno, Valentina Pirota, Matteo Castelli, Elisabetta Moroni, Mariarosaria Ferraro, Paolo Quadrelli, Andrea Rasola, Giorgio Colombo.
METTERE LINK
4. Nitric oxide-based regulation of metabolism: Hints from TRAP1 and SIRT3 crosstalk.
Fiorella Faienza, Andrea Rasola, Giuseppe Filomeni.
Front. Mol. Biosci.
5. MAPK15 protects from oxidative stress-dependent cellular senescence by inducing the mitophagic process.
Lorenzo Franci, Alessandro Tubita, Franca Maria Bertolino, Alessandro Palma, Giuseppe Cannino, Carmine Settembre, Andrea Rasola, Elisabetta Rovida, Mario Chiariello.
Aging cell
2021
1. The molecular chaperone TRAP1 in cancer: From the basics of biology to pharmacological targeting.
Ionica Masgras, Claudio Laquatra, Giuseppe Cannino, Stefano A Serapian, Giorgio Colombo, Andrea Rasola.
Seminars in Cancer Biology
2. SARS-CoV-2 Spike Protein Mutations and Escape from Antibodies: A Computational Model of Epitope Loss in Variants of Concern.
Alice Triveri, Stefano A Serapian, Filippo Marchetti, Filippo Doria, Silvia Pavoni, Fabrizio Cinquini, Elisabetta Moroni, Andrea Rasola, Francesco Frigerio, Giorgio Colombo.
J Chem Inf Model.
3. Defining the molecular mechanisms of the mitochondrial permeability transition through genetic manipulation of F-ATP synthase.
Andrea Carrer, Ludovica Tommasin, Justina Šileikytė, Francesco Ciscato, Riccardo Filadi, Andrea Urbani, Michael Forte, Andrea Rasola, Ildikò Szabò, Michela Carraro, Paolo Bernardi.
Nature Communications
4. Analysis of the Effects of Hexokinase 2 Detachment From Mitochondria-Associated Membranes with the Highly Selective Peptide HK2pep.
Francesco Ciscato, Federica Chiara, Riccardo Filadi, Andrea Rasola.
bio-protocol
5. Targeting the mitochondrial chaperone TRAP1: strategies and therapeutic perspectives.
Stefano A Serapian, Carlos Sanchez-Martín, Elisabetta Moroni, Andrea Rasola, Giorgio Colombo.
Trends in Pharmacological Sciences
6. Neurofibromin Deficiency and Extracellular Matrix Cooperate to Increase Transforming Potential through FAK-Dependent Signaling.
Andrea Errico, Anna Stocco, Vincent M Riccardi, Alberto Gambalunga, Franco Bassetto, Martina Grigatti, Amedeo Ferlosio, Gianluca Tadini, Debora Garozzo, Stefano Ferraresi, Andrea Trevisan, Sandra Giustini, Andrea Rasola, Federica Chiara.
Cancers
7. HIF1α-dependent induction of the mitochondrial chaperone TRAP1 regulates bioenergetic adaptations to hypoxia.
Claudio Laquatra, Carlos Sanchez-Martin, Alberto Dinarello, Giuseppe Cannino, Giovanni Minervini, Elisabetta Moroni, Marco Schiavone, Silvio Tosatto, Francesco Argenton, Giorgio Colombo, Paolo Bernardi, Ionica Masgras, Andrea Rasola.
Cell Death & Disease
8. Hexokinase 2 in Cancer: A Prima Donna Playing Multiple Characters.
Francesco Ciscato, Lavinia Ferrone, Ionica Masgras, Claudio Laquatra, Andrea Rasola.
ijms
9. Low P66shc with High SerpinB3 Levels Favors Necroptosis and Better Survival in Hepatocellular Carcinoma.
Silvano Fasolato, Mariagrazia Ruvoletto, Giorgia Nardo, Andrea Rasola, Marco Sciacovelli, Giacomo Zanus, Cristian Turato, Santina Quarta, Liliana Terrin, Gian Paolo Fadini, Giulio Ceolotto , Maria Guido, Umberto Cillo, Stefano Indraccolo, Paolo Bernardi, Patrizia Pontisso.
Biology
10. Honokiol Bis-Dichloroacetate Is a Selective Allosteric Inhibitor of the Mitochondrial Chaperone TRAP1.
Carlos Sanchez-Martin, Daniela Menon, Elisabetta Moroni, Mariarosaria Ferraro, Ionica Masgras, Justin Elsey, Jack L Arbiser, Giorgio Colombo, Andrea Rasola.
Antioxidants & Redox Signaling
11. Efficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish.
Nicola Facchinello, Claudio Laquatra, Lisa Locatello, Giorgia Beffagna, Raquel Brañas Casas, Chiara Fornetto, Alberto Dinarello, Laura Martorano, Andrea Vettori, Giovanni Risat, Rudy Celeghin, Giacomo Meneghetti, Massimo Mattia Santoro, Agnes Delahodde, Francesco Vanzi, Andrea Rasola, Luisa Dalla Valle, Maria Berica Rasotto, Tiziana Lodi, Enrico Baruffini, Francesco Argenton, Natascia Tiso.
Cell Death & Disease
12. Contribution of the CK2 Catalytic Isoforms α and α' to the Glycolytic Phenotype of Tumor Cells.
Francesca Zonta, Christian Borgo, Camila Paz Quezada Meza, Ionica Masgras, Andrea Rasola, Mauro Salvi, Lorenzo A Pinna, Maria Ruzzene.
cells
13. Machine Learning of Allosteric Effects: The Analysis of Ligand-Induced Dynamics to Predict Functional Effects in TRAP1.
Mariarosaria Ferraro, Elisabetta Moroni, Emiliano Ippoliti, Silvia Rinaldi, Carlos Sanchez-Martin, Andrea Rasola, Luca F Pavarino, Giorgio Colombo.
J Phys Chem B.
2020
1. The Answer Lies in the Energy: How Simple Atomistic Molecular Dynamics Simulations May Hold the Key to Epitope Prediction on the Fully Glycosylated SARS-CoV-2 Spike Protein.
Stefano A Serapian, Filippo Marchetti, Alice Triveri, Giulia Morra, Massimiliano Meli, Elisabetta Moroni, Giuseppe A Sautto, Andrea Rasola, Giorgio Colombo.
J Phys Chem Lett .
2. Dynamically Shaping Chaperones. Allosteric Modulators of HSP90 Family as Regulatory Tools of Cell Metabolism in Neoplastic Progression.
Carlos Sanchez-Martin, Stefano A Serapian, Giorgio Colombo, Andrea Rasola.
Front Oncol .
3. Hexokinase 2 displacement from mitochondria-associated membranes prompts Ca2+ -dependent death of cancer cells.
Francesco Ciscato, Riccardo Filadi, Ionica Masgras, Marco Pizzi, Oriano Marin, Nunzio Damiano, Paola Pizzo, Alessandro Gori, Federica Frezzato, Federica Chiara, Livio Trentin, Paolo Bernardi, Andrea Rasola.
EMBO Rep .
4. Progressively De-Differentiated Pancreatic Cancer Cells Shift from Glycolysis to Oxidative Metabolism and Gain a Quiescent Stem State.
Giulia Ambrosini, Elisa Dalla Pozza, Giuseppina Fanelli, Claudia Di Carlo, Andrea Vettori, Giuseppe Cannino, Chiara Cavallini, Cristian Andres Carmona-Carmona, Jessica Brandi, Sara Rinalducci, Maria Teresa Scupoli, Andrea Rasola, Daniela Cecconi, Marta Palmieri, Ilaria Dando.
Cells
5. S-nitrosylation affects TRAP1 structure and ATPase activity and modulates cell response to apoptotic stimuli.
Fiorella Faienza, Matteo Lambrughi, Salvatore Rizza, Chiara Pecorari, Paola Giglio, Juan Salamanca Viloria, Maria Francesca Allega, Giovanni Chiappetta, Joëlle Vinh, Francesca Pacello, Andrea Battistoni, Andrea Rasola, Elena Papaleo, Giuseppe Filomeni.
Biochem Pharmacol.
6. Thyroid hormone inhibits hepatocellular carcinoma progression via induction of differentiation and metabolic reprogramming.
Marta Anna Kowalik, Elisabetta Puliga, Lavinia Cabras, Pia Sulas, Annalisa Petrelli, Andrea Perra, Giovanna Maria Ledda-Columbano, Andrea Morandi, Simone Merlin, Claudia Orrù, Carlos Sanchez-Martin, Francesca Fornari, Laura Gramantieri, Matteo Parri, Andrea Rasola, Sara Erika Bellomo, Carlos Sebastian, Antonia Follenzi, Silvia Giordano, Amedeo Columbano.
J Hepatol.
7. Rational Design of Allosteric and Selective Inhibitors of the Molecular Chaperone TRAP1.
Carlos Sanchez-Martin, Elisabetta Moroni, Mariarosaria Ferraro, Claudio Laquatra, Giuseppe Cannino, Ionica Masgras, Alessandro Negro, Paolo Quadrelli, Andrea Rasola, Giorgio Colombo.
Cell rep.
2019
1. The zebrafish orthologue of the human hepatocerebral disease gene MPV17 plays pleiotropic roles in mitochondria
Laura Martorano, Margherita Peron, Claudio Laquatra, Elisa Lidron, Nicola Facchinello, Giacomo Meneghetti, Natascia Tiso, Andrea Rasola, Daniele Ghezzi, Francesco Argenton.
Dis Model Mech.
2018
1. Editorial: Redox and Metabolic Circuits in Cancer.
Salvatore Rizza, Andrea Rasola, Danyelle M Townsend, Giuseppe Filomeni.
Front Oncol.
2. Publisher Correction: Compartmentalized activities of the pyruvate dehydrogenase complex sustain lipogenesis in prostate cancer.
Jingjing Chen, Ilaria Guccini, Diletta Di Mitri, Daniela Brina, Ajinkya Revandkar, Manuela Sarti, Emiliano Pasquini, Abdullah Alajati, Sandra Pinton, Marco Losa, Gianluca Civenni, Carlo V Catapano, Jacopo Sgrignani, Andrea Cavalli, Rocco D'Antuono, John M Asara, Andrea Morandi, Paola Chiarugi, Sara Crotti, Marco Agostini, Monica Montopoli, Ionica Masgras, Andrea Rasola, Ramon Garcia-Escudero, Nicolas Delaleu, Andrea Rinaldi, Francesco Bertoni, Johann de Bono, Arkaitz Carracedo, Andrea Alimonti.
Nature genetics.
2017
1. Design of Allosteric Stimulators of the Hsp90 ATPase as New Anticancer Leads.
Ilda D'Annessa, Sara Sattin, Jiahui Tao, Marzia Pennati, Carlos Sànchez-Martìn, Elisabetta Moroni, Andrea Rasola, Nadia Zaffaroni, David A Agard, Anna Bernardi, Giorgio Colombo.
Chemistry.
2. The Chaperone TRAP1 As a Modulator of the Mitochondrial Adaptations in Cancer Cells.
Ionica Masgras, Carlos Sanchez-Martin, Giorgio Colombo, Andrea Rasola.
Front Oncol.
3. HSP90 proteins in the scenario of tumor complexity.
Andrea Rasola.
Oncotarget.
4. Absence of Neurofibromin Induces an Oncogenic Metabolic Switch via Mitochondrial ERK-Mediated Phosphorylation of the Chaperone TRAP1.
Ionica Masgras, Francesco Ciscato, Anna Maria Brunati, Elena Tibaldi, Stefano Indraccolo, Matteo Curtarello, Federica Chiara, Giuseppe Cannino, Elena Papaleo, Matteo Lambrughi, Giulia Guzzo, Alberto Gambalunga, Marco Pizzi, Vincenza Guzzardo, Massimo Rugge, Stefania Edith Vuljan, Fiorella Calabrese, Paolo Bernardi, Andrea Rasola.
Cell rep.
2016
1. S-nitrosylation of the Mitochondrial Chaperone TRAP1 Sensitizes Hepatocellular Carcinoma Cells to Inhibitors of Succinate Dehydrogenase.
Salvatore Rizza, Costanza Montagna, Simone Cardaci, Emiliano Maiani, Giuseppina Di Giacomo, Virginia Sanchez-Quiles, Blagoy Blagoev, Andrea Rasola, Daniela De Zio, Jonathan S Stamler, Francesco Cecconi, Giuseppe Filomeni.
Cancer Res.
2. Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis.
Marta Anna Kowalik, Giulia Guzzo, Andrea Morandi, Andrea Perra, Silvia Menegon, Ionica Masgras, Elena Trevisan, Maria Maddalena Angioni, Francesca Fornari, Luca Quagliata, Giovanna Maria Ledda-Columbano, Laura Gramantieri, Luigi Terracciano, Silvia Giordano, Paola Chiarugi, Andrea Rasola, Amedeo Columbano.
Oncotarget.
3. Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death.
Daniela Catanzaro, Edoardo Gaude, Genny Orso, Carla Giordano, Giulia Guzzo, Andrea Rasola, Eugenio Ragazzi, Laura Caparrotta, Christian Frezza, Monica Montopoli.
Oncotarget.
2015
1. Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death.
Daniela Catanzaro, Edoardo Gaude, Genny Orso, Carla Giordano, Giulia Guzzo, Andrea Rasola, Eugenio Ragazzi, Laura Caparrotta, Christian Frezza, Monica Montopoli.
Oncotarget
2. The Mitochondrial Permeability Transition Pore: Channel Formation by F-ATP Synthase, Integration in Signal Transduction, and Role in Pathophysiology.
Paolo Bernardi, Andrea Rasola, Michael Forte, Giovanna Lippe.
Physiol Rev